Antiviral Therapeutics
Antiviral Therapeutics Market by Drug (Hepatitis Antiviral Drug, Herpes Antiviral Drug, HIV Antiviral Drug), Therapy (DNA Polymerase Inhibitors, Neuraminidase Inhibitors, Protease Inhibitors), Distribution - Global Forecast 2024-2030
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[181 Pages Report] The Antiviral Therapeutics Market size was estimated at USD 75.53 billion in 2023 and expected to reach USD 82.01 billion in 2024, at a CAGR 8.28% to reach USD 131.82 billion by 2030.

Antiviral therapeutics are therapeutics specifically designed to target viral pathogens and inhibit their replication, thereby alleviating the symptoms and spread of viral diseases. Antiviral drugs are used in various healthcare settings, ranging from hospitals to specialty clinics and home care. They are prescribed for the treatment of diverse viral infections, including influenza, hepatitis, Human Immunodeficiency Virus (HIV), Herpes Simplex Virus (HSV), and the recent SARS-CoV-2. The rising prevalence of various chronic and viral diseases worldwide is expanding the need for antiviral therapeutics. Growing pharmaceutical research and development activities with increasing healthcare expenditure are driving the growth of the antiviral therapeutics market. Side effects associated with antiviral drugs high cost of development of medication hampers the growth of antiviral therapeutics. Growing research and development activities to develop antiviral therapeutics by market vendors are expected to create opportunities for market growth.

Regional Insights

In the Americas, the antiviral therapeutics market is highly developing due to the presence of major pharmaceutical companies, advanced healthcare infrastructure, and a high prevalence of viral infections. Innovative treatment regimens and a strong focus on research & development (R&D) have been catalyzed by significant investment from both the public and private sectors. European Union (EU) countries collectively represent a significant market, with overarching regulations governed by the European Medicines Agency (EMA). High standards of healthcare and a relatively wealthy population translate to a strong consumer need for the latest therapeutic options. The prevalence of universal health coverage across many EU countries means that purchasing behavior is largely determined by regulatory endorsements and national health care policies. The Middle East and Africa (MEA) presents a diverse market with varying degrees of access to healthcare. Wealthier nations in the Middle East have the financial resources to invest in modern therapeutics, while many African countries face significant barriers to access. Asia-Pacific region is rapidly expanding its presence in the antiviral therapeutics market, marked by increasing investment in pharmaceutical R&D and a large population base requiring medical treatment. The growing availability of local manufacturing and government initiatives in the region to improve healthcare access is driving market growth in Asia-Pacific.

Antiviral Therapeutics Market
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Market Dynamics

The market dynamics represent an ever-changing landscape of the Antiviral Therapeutics Market by providing actionable insights into factors, including supply and demand levels. Accounting for these factors helps design strategies, make investments, and formulate developments to capitalize on future opportunities. In addition, these factors assist in avoiding potential pitfalls related to political, geographical, technical, social, and economic conditions, highlighting consumer behaviors and influencing manufacturing costs and purchasing decisions.

  • Market Drivers
    • Rising Prevalence of Viral Diseases Including HIV and Hepatitis
    • Application of Antiviral Therapeutics in Pediatric Care and Respiratory Diseases
    • Increasing Initiatives to Curb Viral Diseases by Public and Private Companies
  • Market Restraints
    • Relatively High Cost Associated with Antiviral Drug Treatment
  • Market Opportunities
    • Advancements in Molecular Biology Promoting Drug Development
    • Improved Testing and Analysis of Viral Infections
  • Market Challenges
    • Adverse Effects of Antiviral Drugs
Market Segmentation Analysis
  • Drug: Growing usage of influenza antiviral drugs are used to treat and prevent influenza.

    Hepatitis antiviral drugs are designed to target hepatitis viruses such as HBV (Hepatitis B virus) and HCV (Hepatitis C virus). These drugs are essential for treating chronic hepatitis infections, which can lead to serious liver damage and hepatocellular carcinoma. Medications in this category include nucleoside/nucleotide analogs for HBV and direct-acting antivirals (DAAs) for HCV. Herpes antiviral drugs target the herpes simplex virus (HSV-1 and HSV-2) and varicella-zoster virus (VZV), which causes chickenpox and shingles. These medications, such as acyclovir, valacyclovir, and famciclovir, are critical in managing outbreaks, reducing viral shedding, and decreasing the duration and severity of symptoms. HIV antiviral drugs are a combination of therapies known as antiretroviral therapy (ART), which help manage HIV infection. These drugs do not cure HIV but suppress the virus's replication, thereby improving the quality of life and reducing the risk of HIV transmission. Classes of ART drugs include reverse transcriptase inhibitors, protease inhibitors, integrase inhibitors, and entry inhibitors. Influenza antiviral drugs are used to treat and prevent influenza. These drugs can lessen the symptoms and reduce the time someone is sick by 1-2 days. They can also reduce the severity of the disease and prevent complications such as pneumonia.

  • Therapy: Rising inclination towards DNA polymerase inhibitors for the management of HSV and VZV

    DNA polymerase inhibitors are a class of antiviral drugs designed to block the viral DNA polymerase enzyme, which is essential for viral DNA replication. These agents are particularly significant in the treatment of herpesviruses and certain hepadnaviruses, such as the hepatitis B virus. Their need-based preference is most pronounced among patients who require treatment for conditions including herpes simplex virus (HSV) infections and varicella-zoster virus (VZV), which causes chickenpox and shingles. Neuraminidase inhibitors target the neuraminidase enzyme, which is critical for the release and spread of the influenza virus. They are commonly prescribed for both the treatment and prevention of influenza A and B. The preference for these drugs increases during flu season and in pandemic preparedness scenarios, as they can significantly reduce the severity and duration of flu symptoms if administered promptly. Protease inhibitors disrupt the protease enzyme, which is essential for the maturation of many viruses, including HIV and hepatitis C virus (HCV). This class of drugs is a mainstay in the treatment of HIV/AIDS as part of highly active antiretroviral therapy (HAART) and has gained prominence in the treatment of HCV. Reverse transcriptase inhibitors are antiviral drugs that interfere with the reverse transcriptase enzyme, a key player in the replication of retroviruses, including HIV. Preferences for these medications are especially high in the management of HIV infections to prevent the virus from multiplying and to reduce the viral load to undetectable levels.

  • Distribution: Growing adoption of online pharmacy with the rising digital transformation initiatives

    Hospital pharmacies represent a vital distribution channel for antiviral therapeutics, focusing primarily on inpatient care. These establishments are integral in managing the immediate and acute antiviral needs of patients. Their inventory favors antivirals that are used for emergent, high-priority, or highly regulated treatments that might not be readily available in the retail sector. Hospital pharmacies typically negotiate directly with manufacturers or through group purchasing organizations (GPOs) to obtain favorable pricing. Independent pharmacies and drug stores cater to community health needs and often provide personalized services. These establishments are important for the distribution of antiviral medications that are commonly prescribed for widespread conditions including, influenza or herpes. Independent pharmacies provide a more localized distribution network and may offer competitive options for antiviral acquisition, including generic alternatives, compared to larger chain pharmacies. The adoption of online pharmacy services has been accelerated by the digital transformation and the need for convenient access to medications, including antivirals. Online pharmacies offer doorstep delivery, privacy, and often competitive pricing. They serve a growing population comfortable with e-commerce and seeking to avoid traveling to physical stores, particularly during viral outbreaks.

Market Disruption Analysis

The market disruption analysis delves into the core elements associated with market-influencing changes, including breakthrough technological advancements that introduce novel features, integration capabilities, regulatory shifts that could drive or restrain market growth, and the emergence of innovative market players challenging traditional paradigms. This analysis facilitates a competitive advantage by preparing players in the Antiviral Therapeutics Market to pre-emptively adapt to these market-influencing changes, enhances risk management by early identification of threats, informs calculated investment decisions, and drives innovation toward areas with the highest demand in the Antiviral Therapeutics Market.

Porter’s Five Forces Analysis

The porter's five forces analysis offers a simple and powerful tool for understanding, identifying, and analyzing the position, situation, and power of the businesses in the Antiviral Therapeutics Market. This model is helpful for companies to understand the strength of their current competitive position and the position they are considering repositioning into. With a clear understanding of where power lies, businesses can take advantage of a situation of strength, improve weaknesses, and avoid taking wrong steps. The tool identifies whether new products, services, or companies have the potential to be profitable. In addition, it can be very informative when used to understand the balance of power in exceptional use cases.

Value Chain & Critical Path Analysis

The value chain of the Antiviral Therapeutics Market encompasses all intermediate value addition activities, including raw materials used, product inception, and final delivery, aiding in identifying competitive advantages and improvement areas. Critical path analysis of the <> market identifies task sequences crucial for timely project completion, aiding resource allocation and bottleneck identification. Value chain and critical path analysis methods optimize efficiency, improve quality, enhance competitiveness, and increase profitability. Value chain analysis targets production inefficiencies, and critical path analysis ensures project timeliness. These analyses facilitate businesses in making informed decisions, responding to market demands swiftly, and achieving sustainable growth by optimizing operations and maximizing resource utilization.

Pricing Analysis

The pricing analysis comprehensively evaluates how a product or service is priced within the Antiviral Therapeutics Market. This evaluation encompasses various factors that impact the price of a product, including production costs, competition, demand, customer value perception, and changing margins. An essential aspect of this analysis is understanding price elasticity, which measures how sensitive the market for a product is to its price change. It provides insight into competitive pricing strategies, enabling businesses to position their products advantageously in the Antiviral Therapeutics Market.

Technology Analysis

The technology analysis involves evaluating the current and emerging technologies relevant to a specific industry or market. This analysis includes breakthrough trends across the value chain that directly define the future course of long-term profitability and overall advancement in the Antiviral Therapeutics Market.

Patent Analysis

The patent analysis involves evaluating patent filing trends, assessing patent ownership, analyzing the legal status and compliance, and collecting competitive intelligence from patents within the Antiviral Therapeutics Market and its parent industry. Analyzing the ownership of patents, assessing their legal status, and interpreting the patents to gather insights into competitors' technology strategies assist businesses in strategizing and optimizing product positioning and investment decisions.

Trade Analysis

The trade analysis of the Antiviral Therapeutics Market explores the complex interplay of import and export activities, emphasizing the critical role played by key trading nations. This analysis identifies geographical discrepancies in trade flows, offering a deep insight into regional disparities to identify geographic areas suitable for market expansion. A detailed analysis of the regulatory landscape focuses on tariffs, taxes, and customs procedures that significantly determine international trade flows. This analysis is crucial for understanding the overarching legal framework that businesses must navigate.

Regulatory Framework Analysis

The regulatory framework analysis for the Antiviral Therapeutics Market is essential for ensuring legal compliance, managing risks, shaping business strategies, fostering innovation, protecting consumers, accessing markets, maintaining reputation, and managing stakeholder relations. Regulatory frameworks shape business strategies and expansion initiatives, guiding informed decision-making processes. Furthermore, this analysis uncovers avenues for innovation within existing regulations or by advocating for regulatory changes to foster innovation.

The Rising Prevalence of Viral Diseases Including HIV and Hepatitis from the Antiviral Therapeutics Market Research Report published by 360iResearch provided us with invaluable insights and actionable strategies. Before using the report, we faced significant challenges in addressing the growing threat of viral diseases and lacked a comprehensive market outlook. The report offered a detailed analysis and foresight that allowed us to align our R&D efforts with market needs, identify potential opportunities, and devise effective strategies to address public health concerns. Specific findings from the report enabled us to optimize our resource allocation, improve our product pipeline, and ultimately enhance our market positioning. We couldn't be more satisfied with the positive impact it has had on our operations.
Eli Lilly and Company
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FPNV Positioning Matrix

The FPNV positioning matrix is essential in evaluating the market positioning of the vendors in the Antiviral Therapeutics Market. This matrix offers a comprehensive assessment of vendors, examining critical metrics related to business strategy and product satisfaction. This in-depth assessment empowers users to make well-informed decisions aligned with their requirements. Based on the evaluation, the vendors are then categorized into four distinct quadrants representing varying levels of success, namely Forefront (F), Pathfinder (P), Niche (N), or Vital (V).

Market Share Analysis

The market share analysis is a comprehensive tool that provides an insightful and in-depth assessment of the current state of vendors in the Antiviral Therapeutics Market. By meticulously comparing and analyzing vendor contributions, companies are offered a greater understanding of their performance and the challenges they face when competing for market share. These contributions include overall revenue, customer base, and other vital metrics. Additionally, this analysis provides valuable insights into the competitive nature of the sector, including factors such as accumulation, fragmentation dominance, and amalgamation traits observed over the base year period studied. With these illustrative details, vendors can make more informed decisions and devise effective strategies to gain a competitive edge in the market.

Recent Developments
  • Gilead and Assembly Biosciences Establish Partnership to Develop Next-Generation Therapeutics for Serious Viral Diseases

    Gilead Sciences, Inc. and Assembly Biosciences, Inc. announced a comprehensive 12-year strategic partnership. This alliance is set to boost the development of groundbreaking antiviral agents, concentrating on Assembly Bio’s core competencies in combating herpesviruses, hepatitis B (HBV) and hepatitis D virus (HDV). [Published On: 2023-10-17]

  • FDA Approves First Oral Antiviral for Treatment of COVID-19 in Adults

    The U.S. Food and Drug Administration has officially approved Paxlovid, an oral antiviral regimen consisting of nirmatrelvir and ritonavir tablets specifically designed for at-home administration to treat adult patients with mild-to-moderate COVID-19 who are at an increased risk of developing severe illness, which can lead to hospitalization or even fatality. This authorization marks Paxlovid as the first oral antiviral medication and the fourth therapeutic overall to receive FDA approval for combatting COVID-19 among adults. [Published On: 2023-05-25]

  • Shionogi Advances Ensitrelvir Fumaric Acid COVID-19 Antiviral Clinical Program

    Shionogi & Co., Ltd updated their intensive clinical development initiatives for ensitrelvir, a pioneering oral medication designed to combat COVID-19. Known commercially as Xocova within Japan, ensitrelvir has secured emergency use authorization by Japan's Ministry of Health, Labour and Welfare (MHLW) for treating SARS-CoV-2 infections, based on favorable outcomes in the Asia-conducted Phase 3 segment of a combined Phase 2/3 clinical trial involving non-hospitalized subjects. As Shionogi continues to pursue global recognition, numerous Phase 3 clinical trials are being conducted to validate the safety profile and efficacy of ensitrelvir across diverse patient demographics. [Published On: 2023-02-15]

Strategy Analysis & Recommendation

The strategic analysis is essential for organizations seeking a solid foothold in the global marketplace. Companies are better positioned to make informed decisions that align with their long-term aspirations by thoroughly evaluating their current standing in the Antiviral Therapeutics Market. This critical assessment involves a thorough analysis of the organization’s resources, capabilities, and overall performance to identify its core strengths and areas for improvement.

Before utilizing the 360iResearch Antiviral Therapeutics Market Research Report, we faced significant challenges in accurately assessing the market dynamics and trends of viral infections. The report provided us with invaluable insights and actionable strategies that transformed our approach. With its thorough analysis and strategic recommendations, we improved our testing and analysis processes, leading to more effective antiviral therapies. Specifically, the report's data enabled us to optimize resource allocation and enhance product development timelines. Overall, the report has been instrumental in positively impacting our operations, and we highly recommend it to other industry players seeking substantial growth and innovation.
Novartis AG
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Key Company Profiles

The report delves into recent significant developments in the Antiviral Therapeutics Market, highlighting leading vendors and their innovative profiles. These include Eli Lilly and Company, Novartis AG, Johnson & Johnson Services Inc., Merck & Co., Inc., Syngene International Limited, Dr. Reddy’s Laboratories Ltd., Abbott Laboratories, Cocrystal Pharma, Inc., Atea Pharmaceuticals, Inc., Bristol-Myers Squibb Company, AstraZeneca PLC, Cipla Ltd., GlaxoSmithKline PLC, F. Hoffmann-La Roche Ltd, Daiichi Sankyo Company, Ltd., Pfizer Inc., Sanofi S.A., AbbVie Inc., Sun Pharmaceutical Industries Limited, Alkem Laboratories Limited, Gilead Sciences, Inc., Hetero Labs Limited, Viatris Inc., Takeda Pharmaceutical Company Limited, Themis Medicare Ltd., Aurobindo Pharma Limited, Venatorx Pharmaceuticals, Inc., and Zydus Lifesciences Limited.

Antiviral Therapeutics Market - Global Forecast 2024-2030
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Market Segmentation & Coverage

This research report categorizes the Antiviral Therapeutics Market to forecast the revenues and analyze trends in each of the following sub-markets:

  • Drug
    • Hepatitis Antiviral Drug
    • Herpes Antiviral Drug
    • HIV Antiviral Drug
    • Influenza Antiviral Drug
  • Therapy
    • DNA Polymerase Inhibitors
      • Non-nucleosides
      • Purine Nucleoside Analogues
      • Pyrimidine Nucleoside Analogues
    • Neuraminidase Inhibitors
    • Protease Inhibitors
    • Reverse Transcriptase Inhibitors
      • Nonnucleoside RTIs
      • Nucleoside RTIs
      • Nucleotide RTIs
  • Distribution
    • Hospital Pharmacy
    • Independent Pharmacy & Drug Store
    • Online Pharmacy

  • Region
    • Americas
      • Argentina
      • Brazil
      • Canada
      • Mexico
      • United States
        • California
        • Florida
        • Illinois
        • New York
        • Ohio
        • Pennsylvania
        • Texas
    • Asia-Pacific
      • Australia
      • China
      • India
      • Indonesia
      • Japan
      • Malaysia
      • Philippines
      • Singapore
      • South Korea
      • Taiwan
      • Thailand
      • Vietnam
    • Europe, Middle East & Africa
      • Denmark
      • Egypt
      • Finland
      • France
      • Germany
      • Israel
      • Italy
      • Netherlands
      • Nigeria
      • Norway
      • Poland
      • Qatar
      • Russia
      • Saudi Arabia
      • South Africa
      • Spain
      • Sweden
      • Switzerland
      • Turkey
      • United Arab Emirates
      • United Kingdom

Before utilizing the Antiviral Therapeutics Market Research Report from 360iResearch, our team faced significant challenges in navigating the fast-evolving landscape of molecular biology and drug development. The report provided us with valuable insights and actionable strategies that proved essential in addressing these hurdles. Notably, the advancements in molecular biology outlined in the report allowed us to refine our research and development processes, enhancing our ability to innovate and stay ahead of industry trends. The specific, data-driven findings offered us a competitive edge, ultimately leading to more effective antiviral therapeutics and improved patient outcomes. We are highly satisfied with how this comprehensive report has positively impacted our operations, driving us towards greater success in our field.
Johnson & Johnson Services Inc.
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This research report offers invaluable insights into various crucial aspects of the Antiviral Therapeutics Market:

  1. Market Penetration: This section thoroughly overviews the current market landscape, incorporating detailed data from key industry players.
  2. Market Development: The report examines potential growth prospects in emerging markets and assesses expansion opportunities in mature segments.
  3. Market Diversification: This includes detailed information on recent product launches, untapped geographic regions, recent industry developments, and strategic investments.
  4. Competitive Assessment & Intelligence: An in-depth analysis of the competitive landscape is conducted, covering market share, strategic approaches, product range, certifications, regulatory approvals, patent analysis, technology developments, and advancements in the manufacturing capabilities of leading market players.
  5. Product Development & Innovation: This section offers insights into upcoming technologies, research and development efforts, and notable advancements in product innovation.

Additionally, the report addresses key questions to assist stakeholders in making informed decisions:

  1. What is the current market size and projected growth?
  2. Which products, segments, applications, and regions offer promising investment opportunities?
  3. What are the prevailing technology trends and regulatory frameworks?
  4. What is the market share and positioning of the leading vendors?
  5. What revenue sources and strategic opportunities do vendors in the market consider when deciding to enter or exit?

Table of Contents
  1. Preface
  2. Research Methodology
  3. Executive Summary
  4. Market Overview
  5. Market Insights
  6. Antiviral Therapeutics Market, by Drug
  7. Antiviral Therapeutics Market, by Therapy
  8. Antiviral Therapeutics Market, by Distribution
  9. Americas Antiviral Therapeutics Market
  10. Asia-Pacific Antiviral Therapeutics Market
  11. Europe, Middle East & Africa Antiviral Therapeutics Market
  12. Competitive Landscape
  13. Competitive Portfolio
  14. List of Figures [Total: 22]
  15. List of Tables [Total: 470]
  16. List of Companies Mentioned [Total: 28]
Antiviral therapeutics to beat rapidly multiplying infectious diseases
May 16, 2023
INSIGHT
Antiviral therapeutics to beat rapidly multiplying infectious diseases
Advanced antiviral medicines, a critical tool of today's healthcare industry, are making great strides to counter the spread of infectious illnesses through the power of accelerating R&D and investment activities.

Infectious diseases remain the major causes of human and animal morbidity and mortality, leading to significant healthcare expenditure worldwide. In the past few years, the Integrated Disease Surveillance Programme (IDSP) reported a total of 1683 outbreaks of diseases in India, out of which 71% were caused by viral pathogens.

In a fight against infectious diseases such as malaria, plague, leprosy, and cholera, antiviral therapeutics have proven to attain enormous success in the past. This has encouraged governments and private companies to invest heavily in antivirals.

The National Institute of Allergy and Infectious Diseases (NIAID) awarded more than USD 12 million for developing antiviral therapies to treat viral diseases. The new product development contracts are part of the Antiviral Program for Pandemics (APP), which aims to accelerate the discovery, development, and manufacturing of antiviral medicines.

Inspired by the record breaking creation of messenger RNA vaccines that alleviated the impact of COVID-19, a philanthropist donated USD 172 million to a research center in Melbourne to develop technologies to quickly create antiviral treatments such as monoclonal antibodies for the treatment of emerging infectious diseases.

These financial contributions are proving to be helping hands in elevating the discovery of antiviral therapeutics and reducing the burden of viral diseases across the globe.

Antiviral Therapeutics: Boosting Pediatric Care and Treating Respiratory Diseases
November 2, 2023
BLOG
Antiviral Therapeutics: Boosting Pediatric Care and Treating Respiratory Diseases
The world is currently facing a challenging time owing to the outbreak of COVID-19. The pandemic has thrust the healthcare industry into the limelight, with antiviral therapeutics emerging as a highly effective solution. The antiviral therapeutics market is proliferating, driven by the increasing application of these drugs in pediatric care and respiratory diseases.

The Rising Prevalence of Respiratory Diseases:

Respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and bronchitis have become increasingly common, particularly among children and the elderly. Antiviral therapeutics offer a promising solution to these ailments by alleviating symptoms and reducing infection rates. Furthermore, these drugs have proven effective in reducing hospitalizations and the need for emergency care, reducing the healthcare system's burden.

Advancements in Research and Development:

Research and development of antiviral therapeutics have witnessed a significant boost in recent years, leading to the discovery of new and innovative drugs that offer targeted treatment while reducing the risk of side effects. In addition, a surge in government funding and private investments has enabled the development of advanced therapies that can cater to a wide range of respiratory diseases.

Increased Application in Pediatric Care:

Children are particularly vulnerable to respiratory infections, so antiviral therapeutics are now increasingly being applied in pediatric care. The easy availability of these drugs and the minimal side effects associated with them have made them a popular choice among doctors and parents alike. In addition, antiviral therapeutics effectively reduce the incidence of asthma and other respiratory diseases in children.

Growing Demand for Efficient Therapies:

The rising demand for efficient therapeutics has led to the adoption of antiviral drugs for the treatment of respiratory diseases. These drugs offer a faster response time and are relatively cost-effective, making them a great choice among patients. Furthermore, antiviral drugs have been found to reduce disease transmission rates, leading to a healthier and safer community.

Technological Advancements:

The advent of technology has enabled the development of advanced antiviral therapeutics such as inhalers and nebulizers. These devices offer an efficient delivery mechanism for antiviral drugs, reducing the risk of side effects and providing targeted treatment. Furthermore, advancements in electronic health records and telemedicine have made it easier for doctors to prescribe antiviral drugs to patients remotely.

Antiviral therapeutics have emerged as a highly effective solution to the rising prevalence of respiratory diseases, particularly among children. With advancements in research and development, increased funding, and growing adoption, the antiviral therapeutics market is set to grow rapidly. The future of healthcare looks promising with the increasing application of these drugs and the development of advanced therapies in the near future.

Frequently Asked Questions
  1. How big is the Antiviral Therapeutics Market?
    Ans. The Global Antiviral Therapeutics Market size was estimated at USD 75.53 billion in 2023 and expected to reach USD 82.01 billion in 2024.
  2. What is the Antiviral Therapeutics Market growth?
    Ans. The Global Antiviral Therapeutics Market to grow USD 131.82 billion by 2030, at a CAGR of 8.28%
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