Cryo-electron Microscopy

Cryo-electron Microscopy Market by Technology (Nuclear Magnetic Resonance (NMR) Microscopy, Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM)), Product (Instruments, Services, Software), Voltage, Application, End-User - Global Forecast 2024-2030

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[192 Pages Report] The Cryo-electron Microscopy Market size was estimated at USD 1.23 billion in 2023 and expected to reach USD 1.37 billion in 2024, at a CAGR 10.74% to reach USD 2.52 billion by 2030.

Cryo-electron Microscopy Market
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Cryo-electron microscopy (cryo-EM) is used to visualize the 3D structure of biological macromolecules at high resolution and has revolutionized structural biology by providing detailed insights into the shapes and functions of biomolecules such as proteins, nucleic acids, and complexes. In cryo-EM, samples are rapidly frozen in a thin layer of vitreous ice, which preserves their native state and prevents the formation of crystalline structures or other artifacts. The frozen samples are imaged using an electron microscope at cryogenic temperatures (typically around -180°C). The rising need for cryo‐EM in structural biology to develop 3D structures of biomacromolecules and the increasing use of cryo-electron microscopy in drug discovery & development raised the adoption of cryo-electron microscopy. However, the requirement of huge capital for equipment purchase of cryo-electron microscopy and the lack of skilled professional experts significantly impedes the utilization of cryo-electron microscopy. In addition, emerging technological advancements in cryo-electron microscopes and ongoing funding and investments from private and public for cryo-EM installations are expected to create tremendous opportunities for developing the cryo-electron microscopy market.

Regional Insights

In North America, the increasing research in the development of nanotechnology, rising technological advancements in microscopy, growing research & development investments, and the launch of new products are boosting the adoption of cryo-electron microscopy. In October 2022, Thermo Fisher Scientific launched the Glacios 2 Cryo-Transmission Electron Microscope (Cryo-TEM), which features high-resolution capabilities and helps research drug discovery. In the Asia-Pacific, especially in India and China, the presence of various research institutes and therapeutic studies and the market players are focusing on expanding their manufacturing capabilities, significantly increasing the installation of cryo-electron microscopes. In Europe, governments and multiple technology firms focus on developing nanotechnology due to its rise in numerous applications and are investing in cryo-electron microscope technology. The cryo-electron microscope market in this region is expanding due to an increase in several well-equipped diagnostic centers and ongoing clinical trials.

Market Dynamics

The market dynamics represent an ever-changing landscape of the Cryo-electron Microscopy Market by providing actionable insights into factors, including supply and demand levels. Accounting for these factors helps design strategies, make investments, and formulate developments to capitalize on future opportunities. In addition, these factors assist in avoiding potential pitfalls related to political, geographical, technical, social, and economic conditions, highlighting consumer behaviors and influencing manufacturing costs and purchasing decisions.

Market Disruption Analysis

The market disruption analysis delves into the core elements associated with market-influencing changes, including breakthrough technological advancements that introduce novel features, integration capabilities, regulatory shifts that could drive or restrain market growth, and the emergence of innovative market players challenging traditional paradigms. This analysis facilitates a competitive advantage by preparing players in the Cryo-electron Microscopy Market to pre-emptively adapt to these market-influencing changes, enhances risk management by early identification of threats, informs calculated investment decisions, and drives innovation toward areas with the highest demand in the Cryo-electron Microscopy Market.

Porter’s Five Forces Analysis

The porter's five forces analysis offers a simple and powerful tool for understanding, identifying, and analyzing the position, situation, and power of the businesses in the Cryo-electron Microscopy Market. This model is helpful for companies to understand the strength of their current competitive position and the position they are considering repositioning into. With a clear understanding of where power lies, businesses can take advantage of a situation of strength, improve weaknesses, and avoid taking wrong steps. The tool identifies whether new products, services, or companies have the potential to be profitable. In addition, it can be very informative when used to understand the balance of power in exceptional use cases.

Value Chain & Critical Path Analysis

The value chain of the Cryo-electron Microscopy Market encompasses all intermediate value addition activities, including raw materials used, product inception, and final delivery, aiding in identifying competitive advantages and improvement areas. Critical path analysis of the <> market identifies task sequences crucial for timely project completion, aiding resource allocation and bottleneck identification. Value chain and critical path analysis methods optimize efficiency, improve quality, enhance competitiveness, and increase profitability. Value chain analysis targets production inefficiencies, and critical path analysis ensures project timeliness. These analyses facilitate businesses in making informed decisions, responding to market demands swiftly, and achieving sustainable growth by optimizing operations and maximizing resource utilization.

Pricing Analysis

The pricing analysis comprehensively evaluates how a product or service is priced within the Cryo-electron Microscopy Market. This evaluation encompasses various factors that impact the price of a product, including production costs, competition, demand, customer value perception, and changing margins. An essential aspect of this analysis is understanding price elasticity, which measures how sensitive the market for a product is to its price change. It provides insight into competitive pricing strategies, enabling businesses to position their products advantageously in the Cryo-electron Microscopy Market.

Technology Analysis

The technology analysis involves evaluating the current and emerging technologies relevant to a specific industry or market. This analysis includes breakthrough trends across the value chain that directly define the future course of long-term profitability and overall advancement in the Cryo-electron Microscopy Market.

Patent Analysis

The patent analysis involves evaluating patent filing trends, assessing patent ownership, analyzing the legal status and compliance, and collecting competitive intelligence from patents within the Cryo-electron Microscopy Market and its parent industry. Analyzing the ownership of patents, assessing their legal status, and interpreting the patents to gather insights into competitors' technology strategies assist businesses in strategizing and optimizing product positioning and investment decisions.

Trade Analysis

The trade analysis of the Cryo-electron Microscopy Market explores the complex interplay of import and export activities, emphasizing the critical role played by key trading nations. This analysis identifies geographical discrepancies in trade flows, offering a deep insight into regional disparities to identify geographic areas suitable for market expansion. A detailed analysis of the regulatory landscape focuses on tariffs, taxes, and customs procedures that significantly determine international trade flows. This analysis is crucial for understanding the overarching legal framework that businesses must navigate.

Regulatory Framework Analysis

The regulatory framework analysis for the Cryo-electron Microscopy Market is essential for ensuring legal compliance, managing risks, shaping business strategies, fostering innovation, protecting consumers, accessing markets, maintaining reputation, and managing stakeholder relations. Regulatory frameworks shape business strategies and expansion initiatives, guiding informed decision-making processes. Furthermore, this analysis uncovers avenues for innovation within existing regulations or by advocating for regulatory changes to foster innovation.

FPNV Positioning Matrix

The FPNV positioning matrix is essential in evaluating the market positioning of the vendors in the Cryo-electron Microscopy Market. This matrix offers a comprehensive assessment of vendors, examining critical metrics related to business strategy and product satisfaction. This in-depth assessment empowers users to make well-informed decisions aligned with their requirements. Based on the evaluation, the vendors are then categorized into four distinct quadrants representing varying levels of success, namely Forefront (F), Pathfinder (P), Niche (N), or Vital (V).

Market Share Analysis

The market share analysis is a comprehensive tool that provides an insightful and in-depth assessment of the current state of vendors in the Cryo-electron Microscopy Market. By meticulously comparing and analyzing vendor contributions, companies are offered a greater understanding of their performance and the challenges they face when competing for market share. These contributions include overall revenue, customer base, and other vital metrics. Additionally, this analysis provides valuable insights into the competitive nature of the sector, including factors such as accumulation, fragmentation dominance, and amalgamation traits observed over the base year period studied. With these illustrative details, vendors can make more informed decisions and devise effective strategies to gain a competitive edge in the market.

Recent Developments
  • Gandeeva and Moderna Enter into Cryo-EM Research Collaboration to Explore Protein Surface Structure at Atomic Resolution.

    Cryo-electron microscopy (Cryo-EM) is a revolutionary technology that is revolutionizing the field of structural biology. With the recent collaboration between Gandeeva and Moderna, scientists are now able to explore protein surface structure at unprecedented atomic resolution. This advancement has the potential to unlock insights into molecular function and disease mechanisms which were previously inaccessible. The collaboration between these two research partners therefore offers an opportunity for further exploration which could lead to a greater understanding of proteins and their role in human health. [Published On: 2023-03-30]

  • ATEM Structural Discovery Announces Opening of a Cryo-EM lab in Germany.

    Atem Structural Discovery, a provider of comprehensive cryo-electron microscopy (Cryo-EM) services, recently announced the opening of its first Cryo-EM lab in Germany. This new facility offers companies access to the cutting-edge technology and expertise needed to develop and manufacture novel biopharmaceuticals, biotechnological products and medicines. By leveraging Atem's revolutionary AI assisted imaging platform, customers can optimize throughput and reduce costs associated with high resolution 3D structure determination. [Published On: 2023-03-01]

  • JEOL: Launch of the FIB-SEM System “JIB-PS500i” with High Precision and High Resolution.

    The launch of the new FIB-SEM System “JIB-PS500i” from JEOL offers a combination of high precision and high resolution capabilities that make it ideal for cryo-electron microscopy applications. This product incorporates incredible features such as an enhanced imaging chamber, low acceleration voltage, larger sample sizes, and improved detector readout speed. Its compact design is perfect for laboratories with limited space or budget constraints, making it an attractive choice for researchers looking to maximize their resources. [Published On: 2023-01-31]

Strategy Analysis & Recommendation

The strategic analysis is essential for organizations seeking a solid foothold in the global marketplace. Companies are better positioned to make informed decisions that align with their long-term aspirations by thoroughly evaluating their current standing in the Cryo-electron Microscopy Market. This critical assessment involves a thorough analysis of the organization’s resources, capabilities, and overall performance to identify its core strengths and areas for improvement.

Key Company Profiles

The report delves into recent significant developments in the Cryo-electron Microscopy Market, highlighting leading vendors and their innovative profiles. These include AstraZeneca PLC, ATEM Structural Discovery, Carl Zeiss AG, Charles River Laboratories International, Inc., Creative Biostructure, Delmic B.V., Delong America Inc., Electron Microscopy Sciences, EMphasis, Gandeeva Therapeutics, Inc., Gatan, Inc., Hitachi High-Tech Corporation, Intertek Group PLC, Jena Bioscience GmbH, Jeol Ltd., LeadXpro AG, Leica Microsystems by Danaher Corporation, Linkam Scientific Instruments Ltd., NanoImaging Services, Inc., NovAliX, Oxford Instruments by Spectris PLC, Proteros biostructures GmbH, Protochips, Inc., Quorum Technologies by Judges Scientific PLC, Shuimu BioSciences Ltd., SPT Labtech Ltd., Structura Biotechnology Inc., Thermo Fisher Scientific Inc., and Wuxi Biortus Biosciences Co. Ltd..

Cryo-electron Microscopy Market - Global Forecast 2024-2030
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Market Segmentation & Coverage

This research report categorizes the Cryo-electron Microscopy Market to forecast the revenues and analyze trends in each of the following sub-markets:

  • Technology
    • Nuclear Magnetic Resonance (NMR) Microscopy
    • Scanning Electron Microscopy (SEM)
    • Transmission Electron Microscopy (TEM)
  • Product
    • Instruments
      • Fully Automated Instruments
      • Semi Automated Instruments
    • Services
    • Software
  • Voltage
    • 120 KV
    • 200 KV
    • 300 KV
  • Application
    • Biological Science
    • Lifesciences
    • Material Science
    • Nanotechnology
    • Semiconductor
  • End-User
    • Contract Research Organization
    • Forensic & Diagnostic Laboratories
    • Pharmaceutical & Biotechnology Companies
    • Research Laboratories & Institutes

  • Region
    • Americas
      • Argentina
      • Brazil
      • Canada
      • Mexico
      • United States
        • California
        • Florida
        • Illinois
        • New York
        • Ohio
        • Pennsylvania
        • Texas
    • Asia-Pacific
      • Australia
      • China
      • India
      • Indonesia
      • Japan
      • Malaysia
      • Philippines
      • Singapore
      • South Korea
      • Taiwan
      • Thailand
      • Vietnam
    • Europe, Middle East & Africa
      • Denmark
      • Egypt
      • Finland
      • France
      • Germany
      • Israel
      • Italy
      • Netherlands
      • Nigeria
      • Norway
      • Poland
      • Qatar
      • Russia
      • Saudi Arabia
      • South Africa
      • Spain
      • Sweden
      • Switzerland
      • Turkey
      • United Arab Emirates
      • United Kingdom

This research report offers invaluable insights into various crucial aspects of the Cryo-electron Microscopy Market:

  1. Market Penetration: This section thoroughly overviews the current market landscape, incorporating detailed data from key industry players.
  2. Market Development: The report examines potential growth prospects in emerging markets and assesses expansion opportunities in mature segments.
  3. Market Diversification: This includes detailed information on recent product launches, untapped geographic regions, recent industry developments, and strategic investments.
  4. Competitive Assessment & Intelligence: An in-depth analysis of the competitive landscape is conducted, covering market share, strategic approaches, product range, certifications, regulatory approvals, patent analysis, technology developments, and advancements in the manufacturing capabilities of leading market players.
  5. Product Development & Innovation: This section offers insights into upcoming technologies, research and development efforts, and notable advancements in product innovation.

Additionally, the report addresses key questions to assist stakeholders in making informed decisions:

  1. What is the current market size and projected growth?
  2. Which products, segments, applications, and regions offer promising investment opportunities?
  3. What are the prevailing technology trends and regulatory frameworks?
  4. What is the market share and positioning of the leading vendors?
  5. What revenue sources and strategic opportunities do vendors in the market consider when deciding to enter or exit?

Table of Contents
  1. Preface
  2. Research Methodology
  3. Executive Summary
  4. Market Overview
  5. Market Insights
  6. Cryo-electron Microscopy Market, by Technology
  7. Cryo-electron Microscopy Market, by Product
  8. Cryo-electron Microscopy Market, by Voltage
  9. Cryo-electron Microscopy Market, by Application
  10. Cryo-electron Microscopy Market, by End-User
  11. Americas Cryo-electron Microscopy Market
  12. Asia-Pacific Cryo-electron Microscopy Market
  13. Europe, Middle East & Africa Cryo-electron Microscopy Market
  14. Competitive Landscape
  15. Competitive Portfolio
  16. List of Figures [Total: 26]
  17. List of Tables [Total: 560]
  18. List of Companies Mentioned [Total: 29]
Cryo-electron Microscopy - The Promise of Emerging Technological Advancements
July 16, 2023
Cryo-electron Microscopy - The Promise of Emerging Technological Advancements
As science and technology continue to progress, the capabilities of scientific instruments improve, and new technologies emerge. Cryo-electron microscopy (Cryo-EM) is a relatively new technology that has already revolutionized structural biology, allowing us to visualize the internal structures of biological molecules to an unprecedented level. In this blog post, we'll explore the latest technological advancements in Cryo-EM and examine the promise that these advancements hold for the future of this field.

The Emergence of Single-Particle Cryo-EM:

Cryo-electron microscopy provides a powerful tool to obtain detailed structural information about biological molecules. One of the most significant advancements in Cryo-EM technology is single-particle Cryo-EM. This technique allows scientists to analyze individual molecules without growing large crystals. Researchers can now use single-particle Cryo-EM to visualize the structure of proteins, viruses, and RNA much more quickly and with greater resolution. Single-particle Cryo-EM is an exciting new field that promises to lead to discoveries in many areas of structural biology.

Advances in Imaging Detectors:

In the past few years, there have been significant improvements in the imaging detectors used in Cryo-EM. These new-generation detectors have a higher signal-to-noise ratio, faster readout rates, and can capture more images in less time. Using these detectors, researchers can now collect more data in a shorter time than would have taken weeks or months. This makes it possible to study more complex samples and structures faster than ever before.

The Advantages of Phase Plates:

Phase plates are a relatively new device that researchers can use to enhance the contrast of Cryo-EM images. These plates modify the phase of the electrons, effectively increasing the contrast in the images. With phase plates, researchers can visualize biological molecules with a higher level of detail, leading to more accurate structural information. The use of phase plates is another exciting advancement that has the potential to significantly improve Cryo-EM data quality.

New Visualization Software:

The high-resolution Cryo-EM structural data can be challenging to interpret, and it can take considerable expertise to extract meaningful structural information. Fortunately, there have been significant developments in visualization software in recent years. These new tools can help researchers visualize, analyze, and interpret the complex structural data provided by Cryo-EM. The advent of these new visualization software tools is helping enable rapid structural discovery that would have been impossible previously.

Future Directions:

These recent technological advancements have revolutionized the Cryo-EM field, making it possible to obtain even more detailed and accurate structural information in less time. However, there is still much room for improvement and enhancement, and researchers are already exploring new avenues of innovation. In the future, we can expect to see new hardware improvements, software developments, and advances in sample preparation and handling.

Cryo-EM provides the scientific community access to molecular structures we could only imagine before. With these emerging technologies, cryo-EM demonstrates an unparalleled promise that will lead to discoveries and new insights into the world.

Frequently Asked Questions
  1. How big is the Cryo-electron Microscopy Market?
    Ans. The Global Cryo-electron Microscopy Market size was estimated at USD 1.23 billion in 2023 and expected to reach USD 1.37 billion in 2024.
  2. What is the Cryo-electron Microscopy Market growth?
    Ans. The Global Cryo-electron Microscopy Market to grow USD 2.52 billion by 2030, at a CAGR of 10.74%
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