DNA Sequencing
DNA Sequencing Market by Product & Services (Consumables, Instruments, Services), Technology (Next-Generation Sequencing, Sanger Sequencing, Third Generation DNA Sequencing), Workflow, Application - Global Forecast 2024-2030
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[195 Pages Report] The DNA Sequencing Market size was estimated at USD 60.39 billion in 2023 and expected to reach USD 71.98 billion in 2024, at a CAGR 19.51% to reach USD 210.34 billion by 2030.

DNA sequencing is the laboratory technique determining the sequence of nucleotides or bases in a single DNA molecule. DNA base sequence contains the encoded biological information that cells use to develop and function. DNA sequencing is used for various purposes, including diagnosis & disease treatment, medical research, and forensic analysis. Healthcare professionals can use sequencing to identify gene alterations or mutations of a specific disease condition. Rising cases of genetic disorders & cancer and growing demand for personalized medicine primarily boosting the research & development for DNA sequencing. Furthermore, technical limitations associated with DNA sequencing and the high cost of the sequencing platform limit the DNA sequencing market growth. In addition, complex data analysis & lack of standardized protocols lead to variability in the results of DNA sequencing. Moreover, the increasing adoption of DNA sequencing in clinical and research applications and the adoption of novel sequencing technologies, including next-generation sequencing, are expected to create lucrative opportunities for market growth. The rising investments in genomics research contribute to market growth.

Regional Insights

The Americas has a significant landscape in the DNA sequencing market owing to continuous technological developments by key players, high research and development investment, and availability of technologically advanced healthcare infrastructure, resulting in lucrative market growth in the forecasted period. Government initiatives in the U.S. and Canada supporting research in drug development and treatment of cancer have created significant market growth in North America. In Europe, the growing usage of DNA sequencing in laboratories, rising R&D, and increasing advancements in DNA sequencing technologies have created significant regional development. Asia-Pacific has a growing market in DNA sequencing due to strategic initiatives undertaken by international firms to expand their presence owing to the high customer base, which is expected to create market growth in the region.

DNA Sequencing Market
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Market Dynamics

The market dynamics represent an ever-changing landscape of the DNA Sequencing Market by providing actionable insights into factors, including supply and demand levels. Accounting for these factors helps design strategies, make investments, and formulate developments to capitalize on future opportunities. In addition, these factors assist in avoiding potential pitfalls related to political, geographical, technical, social, and economic conditions, highlighting consumer behaviors and influencing manufacturing costs and purchasing decisions.

  • Market Drivers
    • Increasing cases of genetic disorders across the world
    • Increasing role of NGS in companion diagnostics and personalized medicines
    • Growing usage of DNA sequencing across agrigenomics and forensics
  • Market Restraints
    • Technical limitations associated with DNA sequencing
  • Market Opportunities
    • Advancements and developments in DNA sequencing
    • Rising investments in DNA sequencing and single-cell sequencing
  • Market Challenges
    • Issues associated with the accuracy, reliability, and ethical implications of DNA sequencing
Market Segmentation Analysis
  • Product & Services: Evolution across services with advances in bioinformatics and computational biology

    Consumables are integral to DNA sequencing, encompassing all the necessary reagents, kits, and chemicals used during sequencing. These include DNA preparation kits, library preparation kits, and sequencing reagents. The quality and type of consumables directly impact the sequencing operation's accuracy, efficiency, and cost-effectiveness. Continuous innovation in consumables is critical for enhancing sequencing performance and reducing the per-sample cost, thereby making DNA sequencing more accessible for a broader range of applications. Instruments are the core hardware used in DNA sequencing, which ranges from high-throughput sequencers capable of processing thousands of genomes simultaneously to smaller, more portable devices designed for rapid and on-site analysis. The choice of instrument depends on the scale of sequencing needed, the level of detail required, and the available budget. Innovations in this segment focus on improving speed, reducing costs, and enhancing the resolution and fidelity of the sequencing results. Developing user-friendly interfaces and more compact designs also plays a significant role in adopting sequencing technology in new markets and applications. Services in DNA sequencing encompass a wide array of offerings, from sequencing-as-a-service to data analysis and consulting. These services are particularly important for entities needing more in-house infrastructure or expertise to perform sequencing. Service providers offer sequencing and valuable analysis and interpretation of complex data to provide actionable insights. This segment is evolving rapidly, with advances in bioinformatics and computational biology enhancing the scope and quality of the insights that can be derived from sequencing data, thereby offering tailored solutions to meet the diverse needs of customers.

  • Technology: Growing popularity of next-generation sequencing (NGS) for ultra-high throughput

    Next-generation sequencing (NGS) technology represents a high-throughput approach that helps rapidly sequence the base pairs in DNA samples. NGS allows for the sequencing of multiple DNA strands simultaneously, drastically reducing the time and cost of genomic research. Targeted sequencing & resequencing focuses on sequencing specific areas of interest within a genome, such as regions containing mutations contributing to disease. This provides a cost-effective way to analyze genetic variation in targeted regions. Whole exome sequencing involves sequencing all the protein-coding regions of genes in a genome. These regions, known as exons, comprise about 1%-2% of the human genome and contain about 85% of known genetic mutations linked to diseases. Whole Genome Sequencing (WGS) involves sequencing the entire genome that provides an overview of the entire genetic makeup of an organism, allowing researchers to understand both coding and non-coding regions and their potential mutations or variations. Sanger sequencing is regarded as the first-generation sequencing technique and is a method for determining DNA nucleotide sequences. It has been pivotal in the development of DNA sequencing technologies and remains a gold standard for small-scale DNA sequencing projects. Third-generation DNA sequencing, also known as long-read sequencing, allows for the sequencing of single molecules of DNA in real-time. This technology surpasses previous limitations by generating longer reads, critical for understanding complex genomic regions. Nanopore sequencing is a form of third-generation sequencing that involves threading single DNA strands through nanoscopic pores. As the DNA passes through, changes in the electrical conductivity are used to identify the base sequence; this method allows for real-time analysis of long DNA or RNA fragments. Single-molecule real-time (SMRT) sequencing is characterized by its ability to read single molecules of DNA with high accuracy. This method provides advantages in detecting epigenetic modifications and offers high-quality long reads, enabling comprehensive views of genomes, transcriptomes, and epigenomes.

  • Workflow: Rising preference for sequencing methods to meet accuracy requirements

    The pre-sequencing phase is a critical first step in the DNA sequencing workflow, where samples are collected, assessed for quality, and prepared for the sequencing process. This stage involves DNA extraction from the sample material, quantification to determine the amount of DNA present, and sometimes fragmentation, where the DNA is broken down into smaller pieces. Ensuring the integrity and purity of the DNA at this stage is paramount for successful sequencing outcomes. During the sequencing phase, the actual determination of the DNA sequence takes place. This can be performed using various technologies, such as Sanger sequencing for shorter DNA strands or Next-Generation Sequencing (NGS) for comprehensive, large-scale genomic studies. NGS techniques allow for the parallel sequencing of millions of DNA fragments, providing a high-throughput approach to genome sequencing. This stage generates vast raw sequence data, requiring significant computational effort to analyze. The data analysis phase involves converting the raw sequencing data into an interpretable format. This process, often referred to as bioinformatics, includes tasks such as aligning the sequences against reference genomes, identifying variations/mutations, and annotating genomic features. Advanced computational tools and algorithms are employed to handle the complex data, making drawing biological conclusions from the sequence information possible. The end goal is to provide insights into the sequenced genome's genetic structure, function, and variations.

  • Application: Expanding application of DNA sequencing in clinical investigation for precise diagnosis and understanding of genetic disorders

    Agrigenomics uses genomic insights to improve crop yield, disease resistance, and adaptability to environmental changes for enhanced food security and agricultural practices. In forensics, DNA sequencing facilitates the identification of individuals in criminal investigations, disaster victim identification, and heritage testing, significantly improving the accuracy of forensic analysis. DNA sequencing in clinical investigations enables precise diagnosis, treatment, and understanding of genetic disorders. By sequencing an individual's genome, healthcare professionals detect mutations responsible for diseases, guide personalized treatment plans, and predict disease susceptibility, revolutionizing patient care and preventive medicine. Consumer genomics, a burgeoning segment of DNA sequencing, gives individuals insights into their genetic makeup, ancestry, traits, and predispositions to certain health conditions. This democratization of genomic information fosters an informed and proactive approach to health and wellness among consumers. HLA typing, or human leukocyte antigen typing in DNA sequencing, is pivotal in immune system monitoring, particularly for organ transplantation suitability, disease association studies, and drug hypersensitivity reactions. This application ensures the compatibility between donors and recipients, mitigating the risk of transplant rejection and facilitating targeted therapies. Metagenomics and epidemiology involve the analysis of genetic material from complex microbial communities, offering insights into biodiversity, microbial ecology, and the role of microbes in human health. This knowledge is instrumental in tracking disease outbreaks, understanding pathogen spread, and developing drugs. In drug development, DNA sequencing accelerates the discovery of novel therapeutic targets and mechanisms, enhancing the efficacy and safety of new drugs. Oncology benefits significantly from DNA sequencing by enabling the identification of genetic mutations associated with cancer, which facilitates the development of targeted therapy and personalized medicine approaches, improving cancer patients' survival rates and quality of life through more effective and less toxic treatments.

Market Disruption Analysis

The market disruption analysis delves into the core elements associated with market-influencing changes, including breakthrough technological advancements that introduce novel features, integration capabilities, regulatory shifts that could drive or restrain market growth, and the emergence of innovative market players challenging traditional paradigms. This analysis facilitates a competitive advantage by preparing players in the DNA Sequencing Market to pre-emptively adapt to these market-influencing changes, enhances risk management by early identification of threats, informs calculated investment decisions, and drives innovation toward areas with the highest demand in the DNA Sequencing Market.

Porter’s Five Forces Analysis

The porter's five forces analysis offers a simple and powerful tool for understanding, identifying, and analyzing the position, situation, and power of the businesses in the DNA Sequencing Market. This model is helpful for companies to understand the strength of their current competitive position and the position they are considering repositioning into. With a clear understanding of where power lies, businesses can take advantage of a situation of strength, improve weaknesses, and avoid taking wrong steps. The tool identifies whether new products, services, or companies have the potential to be profitable. In addition, it can be very informative when used to understand the balance of power in exceptional use cases.

Value Chain & Critical Path Analysis

The value chain of the DNA Sequencing Market encompasses all intermediate value addition activities, including raw materials used, product inception, and final delivery, aiding in identifying competitive advantages and improvement areas. Critical path analysis of the <> market identifies task sequences crucial for timely project completion, aiding resource allocation and bottleneck identification. Value chain and critical path analysis methods optimize efficiency, improve quality, enhance competitiveness, and increase profitability. Value chain analysis targets production inefficiencies, and critical path analysis ensures project timeliness. These analyses facilitate businesses in making informed decisions, responding to market demands swiftly, and achieving sustainable growth by optimizing operations and maximizing resource utilization.

Pricing Analysis

The pricing analysis comprehensively evaluates how a product or service is priced within the DNA Sequencing Market. This evaluation encompasses various factors that impact the price of a product, including production costs, competition, demand, customer value perception, and changing margins. An essential aspect of this analysis is understanding price elasticity, which measures how sensitive the market for a product is to its price change. It provides insight into competitive pricing strategies, enabling businesses to position their products advantageously in the DNA Sequencing Market.

Technology Analysis

The technology analysis involves evaluating the current and emerging technologies relevant to a specific industry or market. This analysis includes breakthrough trends across the value chain that directly define the future course of long-term profitability and overall advancement in the DNA Sequencing Market.

Patent Analysis

The patent analysis involves evaluating patent filing trends, assessing patent ownership, analyzing the legal status and compliance, and collecting competitive intelligence from patents within the DNA Sequencing Market and its parent industry. Analyzing the ownership of patents, assessing their legal status, and interpreting the patents to gather insights into competitors' technology strategies assist businesses in strategizing and optimizing product positioning and investment decisions.

Trade Analysis

The trade analysis of the DNA Sequencing Market explores the complex interplay of import and export activities, emphasizing the critical role played by key trading nations. This analysis identifies geographical discrepancies in trade flows, offering a deep insight into regional disparities to identify geographic areas suitable for market expansion. A detailed analysis of the regulatory landscape focuses on tariffs, taxes, and customs procedures that significantly determine international trade flows. This analysis is crucial for understanding the overarching legal framework that businesses must navigate.

Regulatory Framework Analysis

The regulatory framework analysis for the DNA Sequencing Market is essential for ensuring legal compliance, managing risks, shaping business strategies, fostering innovation, protecting consumers, accessing markets, maintaining reputation, and managing stakeholder relations. Regulatory frameworks shape business strategies and expansion initiatives, guiding informed decision-making processes. Furthermore, this analysis uncovers avenues for innovation within existing regulations or by advocating for regulatory changes to foster innovation.

FPNV Positioning Matrix

The FPNV positioning matrix is essential in evaluating the market positioning of the vendors in the DNA Sequencing Market. This matrix offers a comprehensive assessment of vendors, examining critical metrics related to business strategy and product satisfaction. This in-depth assessment empowers users to make well-informed decisions aligned with their requirements. Based on the evaluation, the vendors are then categorized into four distinct quadrants representing varying levels of success, namely Forefront (F), Pathfinder (P), Niche (N), or Vital (V).

Market Share Analysis

The market share analysis is a comprehensive tool that provides an insightful and in-depth assessment of the current state of vendors in the DNA Sequencing Market. By meticulously comparing and analyzing vendor contributions, companies are offered a greater understanding of their performance and the challenges they face when competing for market share. These contributions include overall revenue, customer base, and other vital metrics. Additionally, this analysis provides valuable insights into the competitive nature of the sector, including factors such as accumulation, fragmentation dominance, and amalgamation traits observed over the base year period studied. With these illustrative details, vendors can make more informed decisions and devise effective strategies to gain a competitive edge in the market.

Recent Developments
  • Ultima Genomics Launching High-end DNA Sequencers that can Read Genome for USD 100

    Ultima Genomics introduced its cutting-edge UG 100 sequence, priced at USD 1.5 million. This advanced sequencing instrument possesses the capability to sequence up to 20,000 human genomes annually. Remarkably, the operational cost for reagents is impressively low, at just USD 1 per billion sequenced DNA bases. This efficiency equates to a mere USD 100 for the sequencing of a complete human genome, assuming the sequencing of each of the 3 billion base pairs in the human genome is performed 33 times, aligning with the industry's standard practice. [Published On: 2024-01-30]

  • GBP 46.3 Million Funding Boost to Shine Light on Dark Genome

    An MRC Human Genetics Unit from the University of Edinburgh has been granted a substantial GBP 46.3 million investment by the Medical Research Council (MRC) to bolster its work over the next five years, focusing on pioneering research into the 'dark genome.' This strategic funding marks a significant leap in genomics research in the UK to transform raw genomic data into actionable insights for tackling genetic conditions and improving patient outcomes. [Published On: 2024-01-25]

  • BD, Hamilton Collaborate to Standardize Single-Cell Multiomics Experiments Using Robotics

    Becton, Dickinson, and Company (BD) entered into a synergistic alliance with Hamilton to spearhead the development of automated solutions alongside robotics-compatible reagent kits. This collaboration aims to revolutionize large-scale single-cell multiomics experiments by significantly elevating standardization and minimizing human error. Through the fusion of BD's expertise in single-cell analysis and Hamilton's prowess in automation, the initiative unveils a series of BD Rhapsody Single-Cell Analysis Library Preparation Reagent Kits optimized for use on the Hamilton Microlab NGS STAR robotic liquid-handling platform. [Published On: 2024-01-23]

Strategy Analysis & Recommendation

The strategic analysis is essential for organizations seeking a solid foothold in the global marketplace. Companies are better positioned to make informed decisions that align with their long-term aspirations by thoroughly evaluating their current standing in the DNA Sequencing Market. This critical assessment involves a thorough analysis of the organization’s resources, capabilities, and overall performance to identify its core strengths and areas for improvement.

Key Company Profiles

The report delves into recent significant developments in the DNA Sequencing Market, highlighting leading vendors and their innovative profiles. These include 10x Genomics, Inc., Abbott Laboratories, AbbVie Inc., Agilent Technologies, Inc., Azenta, Inc., Becton, Dickinson and Company, BGI Genomics Co., Ltd., Bio-Rad Laboratories, Inc., BioChain Institute Inc., Charles River Laboratories International, Inc., Danaher Corporation, Dante Labs Inc., Eppendorf SE, Eurofins Scientific SE, F. Hoffmann-La Roche Ltd., Genomics England, Genscript Biotech Corporation, Illumina, Inc., Johnson & Johnson Services, Inc., Konica Minolta, Inc., Laboratory Corporation of America Holdings, Macrogen Inc., Merck KGaA, Novartis AG, Novogene Co, Ltd., Oxford Nanopore Technologies PLC, Pacific Biosciences of California, Inc., PerkinElmer, Inc., QIAGEN N.V., Sartorius AG, Shimadzu Corporation, SOPHiA GENETICS SA, Thermo Fisher Scientific Inc., Twist Bioscience Corporation, and Veritas Genetics Inc. by LetsGetChecked.

DNA Sequencing Market - Global Forecast 2024-2030
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Market Segmentation & Coverage

This research report categorizes the DNA Sequencing Market to forecast the revenues and analyze trends in each of the following sub-markets:

  • Product & Services
    • Consumables
    • Instruments
    • Services
  • Technology
    • Next-Generation Sequencing
      • Targeted Sequencing & Resequencing
      • Whole Exome Sequencing
      • Whole Genome Sequencing
    • Sanger Sequencing
    • Third Generation DNA Sequencing
      • Nanopore Sequencing
      • Single-Molecule Real-Time Sequencing
  • Workflow
    • Data Analysis
    • Pre-Sequencing
    • Sequencing
  • Application
    • Agrigenomics & Forensics
    • Clinical Investigation
    • Consumer Genomics
    • HLA Typing or Immune System Monitoring
    • Metagenomics, Epidemiology & Drug Development
    • Oncology
    • Reproductive Health

  • Region
    • Americas
      • Argentina
      • Brazil
      • Canada
      • Mexico
      • United States
        • California
        • Florida
        • Illinois
        • New York
        • Ohio
        • Pennsylvania
        • Texas
    • Asia-Pacific
      • Australia
      • China
      • India
      • Indonesia
      • Japan
      • Malaysia
      • Philippines
      • Singapore
      • South Korea
      • Taiwan
      • Thailand
      • Vietnam
    • Europe, Middle East & Africa
      • Denmark
      • Egypt
      • Finland
      • France
      • Germany
      • Israel
      • Italy
      • Netherlands
      • Nigeria
      • Norway
      • Poland
      • Qatar
      • Russia
      • Saudi Arabia
      • South Africa
      • Spain
      • Sweden
      • Switzerland
      • Turkey
      • United Arab Emirates
      • United Kingdom

This research report offers invaluable insights into various crucial aspects of the DNA Sequencing Market:

  1. Market Penetration: This section thoroughly overviews the current market landscape, incorporating detailed data from key industry players.
  2. Market Development: The report examines potential growth prospects in emerging markets and assesses expansion opportunities in mature segments.
  3. Market Diversification: This includes detailed information on recent product launches, untapped geographic regions, recent industry developments, and strategic investments.
  4. Competitive Assessment & Intelligence: An in-depth analysis of the competitive landscape is conducted, covering market share, strategic approaches, product range, certifications, regulatory approvals, patent analysis, technology developments, and advancements in the manufacturing capabilities of leading market players.
  5. Product Development & Innovation: This section offers insights into upcoming technologies, research and development efforts, and notable advancements in product innovation.

Additionally, the report addresses key questions to assist stakeholders in making informed decisions:

  1. What is the current market size and projected growth?
  2. Which products, segments, applications, and regions offer promising investment opportunities?
  3. What are the prevailing technology trends and regulatory frameworks?
  4. What is the market share and positioning of the leading vendors?
  5. What revenue sources and strategic opportunities do vendors in the market consider when deciding to enter or exit?

Table of Contents
  1. Preface
  2. Research Methodology
  3. Executive Summary
  4. Market Overview
  5. Market Insights
  6. DNA Sequencing Market, by Product & Services
  7. DNA Sequencing Market, by Technology
  8. DNA Sequencing Market, by Workflow
  9. DNA Sequencing Market, by Application
  10. Americas DNA Sequencing Market
  11. Asia-Pacific DNA Sequencing Market
  12. Europe, Middle East & Africa DNA Sequencing Market
  13. Competitive Landscape
  14. Competitive Portfolio
  15. List of Figures [Total: 24]
  16. List of Tables [Total: 562]
  17. List of Companies Mentioned [Total: 35]
Unravelling the Genetic Code with DNA Sequencing Technologies
September 28, 2023
Unravelling the Genetic Code with DNA Sequencing Technologies
DNA sequencing technology has also paved the way for developing targeted therapies, precision medicine approaches, and improved diagnostic methods while expanding the scope of genomics research into cancer genomics, microbiome analysis, and population genetics.

Genomics is a relatively new scientific discipline, with DNA sequencing as its core technology for studying genetic diseases, their evolution, and biodiversity. The technology has advanced with first-generation methods enabling sequencing of clonal DNA populations, second-generation increasing throughput by parallelizing many reactions, and third-generation plans allowing direct sequencing of single DNA molecules.

Today, the highly decreasing cost of next-generation sequencing data creation has made the large-scale investigation of rare diseases within reach, causing a shift in the field of complex disease diagnostics over the past five years. Governments across India, the United States, Canada, and Europe have invested in private laboratories to scale up genomic surveillance and technology development.

Artificial intelligence (AI) has emerged in genomics to catalyze gene activation research and uncover rare DNA sequences. In 2023, University of California San Diego researchers announced using AI to identify an enigmatic puzzle piece tied to gene activation.

Recent advancements have focused on faster and more accurate sequencing, reduced costs, and improved data analysis, promising to unlock new insights into genomics and improve one’s understanding of diseases and personalized healthcare.

How DNA Sequencing is Revolutionizing Agrigenomics and Forensics
June 26, 2023
How DNA Sequencing is Revolutionizing Agrigenomics and Forensics
DNA sequencing is a rapidly growing field that has the potential to change the future of medicine, genetics, and beyond. Sequencing technology is used in several industries, especially in agriculture, forensics, and medical research.

DNA Sequencing in Agrigenomics:

In the agricultural industry, DNA sequencing technology is used to enhance crop yields and improve quality. DNA sequencing helps to identify the genetic makeup of different crops, and scientists can analyze the genes of different plants to identify traits that improve resistance to diseases, pests, or environmental conditions.

With DNA sequencing, farmers can use the data to select the best crops that will thrive in their particular climate conditions. This technology is also used to track the evolutionary progress of different crops, making it easier for scientists to identify specific genes that cause or protect from diseases and pests that threaten crops.

DNA Sequencing in Forensic Science:

Forensic scientists use DNA sequencing to analyze evidence found at crime scenes or identify remains. DNA sequencing technology has revolutionized forensic science by providing a more accurate and reliable way to identify suspects.

With DNA sequencing, forensic scientists can analyze different genetic markers in the DNA and compare them to a database of samples. This technology often plays a crucial role in solving complex cases where traditional methods have failed to provide answers. DNA sequencing has been instrumental in providing conclusive evidence in DNA-related cases, including paternity disputes and missing person cases.

Benefits of DNA Sequencing:

DNA sequencing technology is widely used in agriculture and forensics because of its several benefits. One of the main advantages of DNA sequencing is that it provides accurate and reliable results. Unlike traditional techniques, DNA sequencing can analyze thousands of genes at once, and the results can be available in real-time. The technology is also cost-efficient, making it more accessible to both industry professionals and consumers.

Future of DNA Sequencing:

As the technology continues to evolve, DNA sequencing is set to become even more crucial in several fields. The agriculture industry is already realizing the benefits of DNA sequencing, and we can expect more companies to adopt the technology to boost crop production. Forensic scientists are also using DNA sequencing to identify individuals with high accuracy and reliability, and we anticipate the adoption of this technology to grow.

DNA sequencing technology has revolutionized many industries, particularly in agrigenomics and forensic science. DNA sequencing can accurately identify plant genetic markers, making it possible to produce crops resistant to pests and diseases. Forensic scientists also rely on DNA sequencing to identify suspects and make more accurate identifications of remains. DNA sequencing has several benefits, including improved accuracy, reliability, and cost-efficiency, making it a preferred method of DNA analysis. As technology continues to evolve, we can expect DNA sequencing to play an even more significant role in many fields, including medicine and genetics.

Frequently Asked Questions
  1. How big is the DNA Sequencing Market?
    Ans. The Global DNA Sequencing Market size was estimated at USD 60.39 billion in 2023 and expected to reach USD 71.98 billion in 2024.
  2. What is the DNA Sequencing Market growth?
    Ans. The Global DNA Sequencing Market to grow USD 210.34 billion by 2030, at a CAGR of 19.51%
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