Preimplantation Genetic Testing
Preimplantation Genetic Testing Market by Technology (Comparative Genomic Hybridization, Fluorescence in-Situ Hybridization, Next-Generation Sequencing), Offering (Instruments, Reagents & Consumables, Software & Services), Procedure Type, Application, End User - Global Forecast 2024-2030
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[180 Pages Report] The Preimplantation Genetic Testing Market size was estimated at USD 728.40 million in 2023 and expected to reach USD 829.06 million in 2024, at a CAGR 14.56% to reach USD 1,886.28 million by 2030.

Preimplantation genetic testing (PGT) refers to technologies used to detect chromosomal abnormalities affecting the embryos before implantation. PGT is a crucial service that allows for early detection of genetic abnormalities in embryos before implantation during in-vitro fertilization (IVF) procedures, significantly reducing the risk of passing on inheritable diseases to offspring and improving IVF success rates. The primary application areas for PGT include identifying monogenic disorders, chromosomal abnormalities, mitochondrial diseases, and human leukocyte antigen (HLA) matching for potential siblings. The rising infertility rates due to lifestyle changes and delayed parenthood choices among couples have necessitated the development of PGT technologies. Government initiatives promoting IVF treatments create numerous expansion opportunities. However, high costs associated with IVF treatments and PGT procedures can be a major deterrent to potential end-users. Ethical concerns surrounding PGT and limited insurance coverage for IVF treatments hinder the adoption of PGT services. Major biotechnology companies are rapidly expanding efforts to combat ethical and regulatory challenges and creating technologies that take moral and ethical issues under consideration. New approaches such as next-generation sequencing (NGS) and non-invasive preimplantation testing are emerging technologies that offer significant potential for the growth of the technology.

Regional Insights

The Americas exhibit a high need for preimplantation genetic testing (PGT) owing to rising infertility rates caused by lifestyle changes and increasing awareness regarding genetic testing. Well-established healthcare infrastructure facilities and favorable reimbursement policies have made PGT services more accessible to couples seeking infertility treatments in the Americas. Companies in the region have strong R&D capabilities and government support that drive innovation in the field. Asia is emerging as a big and opportunistic market for PGT owing to improved provision of advanced fertility techniques such as IVF with PGT services and growing medical tourism, attracting international patients seeking cost-effective treatment options. Europe contributes significantly to the global PGT market due to factors such as increased government funding for healthcare research and widespread adoption of IVF procedures across various European countries. Moreover, stringent regulatory frameworks surrounding genetic testing ensure quality control and ethical considerations when implementing PGT services. Key players within this region contribute significantly to technological advancements in preimplantation genetic testing practices.

Preimplantation Genetic Testing Market
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Market Dynamics

The market dynamics represent an ever-changing landscape of the Preimplantation Genetic Testing Market by providing actionable insights into factors, including supply and demand levels. Accounting for these factors helps design strategies, make investments, and formulate developments to capitalize on future opportunities. In addition, these factors assist in avoiding potential pitfalls related to political, geographical, technical, social, and economic conditions, highlighting consumer behaviors and influencing manufacturing costs and purchasing decisions.

  • Market Drivers
    • Significant incidences of fetal abnormalities and need for healthy and successful embryo implantation
    • Increase in the rate of infertility and the rising number of fertility clinics worldwide
    • Growing early diagnostic approaches coupled with increasing government support to treat genetic diseases
  • Market Restraints
    • Limitation and risks associated with PGT
  • Market Opportunities
    • Technological advancement in the field of preimplantation genetic analysis
    • Emerging startup ecosystem and investments in the field of preimplantation genetic testing
  • Market Challenges
    • Ethical constraints and Misuse of PGT
Market Segmentation Analysis
  • Technology: Advancements in next-generation sequencing to detect chromosomal abnormalities and single-gene disorders

    Comparative genomic hybridization (CGH) is adopted for detecting chromosomal imbalances by comparing the DNA of two samples. It can detect chromosomal abnormalities in embryos before implantation and help select healthy embryos for IVF. Fluorescence in situ hybridization (FISH) is a technique that uses fluorescent probes to visualize and map specific DNA sequences on chromosomes within cells. It can detect numerical chromosomal abnormalities, including aneuploidy or translocations. Next-generation sequencing (NGS) is a robust tool for preimplantation genetic testing owing to its ability to sequence large amounts of DNA quickly and accurately. Polymerase chain reaction (PCR) is a widely used molecular biology technique that amplifies specific DNA sequences for analysis and can detect monogenic diseases. Single-nucleotide polymorphism (SNP) evaluates variations at the single-nucleotide level within the genome and is used to identify carriers of inherited diseases or assess the risk of multifactorial disorders, including cancer.

  • Offering: Utilization of diverse offerings to optimize process conditions and derive accurate results

    Instruments play a critical role in the PGT process as they enable accurate and efficient genetic screening of embryos. Key instruments include next-generation sequencers (NGS), quantitative PCR (qPCR) systems, and fluorescence in situ hybridization (FISH) analyzers. NGS offers high-throughput sequencing capabilities and a broader detection range, making it suitable for detecting single-gene disorders and chromosomal abnormalities. Reagents and consumables used for PGT consist of various kits, probes, buffers, enzymes, and solutions necessary for genetic testing procedures. Probes are vital in detecting specific chromosomal aberrations, and buffers provide appropriate conditions for optimal amplification conditions. Software and services are essential components of PGT, as they ensure reliable data management, analysis, interpretation, and reporting for genetic testing results. Need-based preferences revolve around user-friendly interfaces, accurate algorithms for variant detection, comprehensive databases for variant annotation, and secure data storage options.

  • Procedure: Increasing deployment of preimplantation genetic diagnosis (PGD) procedures to reduce the risk of genetic disorders

    Preimplantation genetic diagnosis (PGD) is a specialized procedure that allows the identification of genetic mutations or chromosomal abnormalities in embryos diagnosed before implantation and pregnancy. The primary goal of PGD is to reduce the risk of developing specific genetic disorders such as cystic fibrosis, Huntington's disease, and muscular dystrophy. Preimplantation genetic screening (PGS), referred to as preimplantation genetic testing for aneuploidies (PGT-A), detects chromosomal aneuploidies or imbalances in embryos before implantation. PGS aims to improve the chances of successful pregnancies by identifying embryos with the correct number of chromosomes, reducing the risk of miscarriage, stillbirth, or having a child affected by Down syndrome or other chromosomal abnormalities.

  • Application: Wide use of preimplantation genetic testing for aneuploidy disorder

    Aneuploidy is a disorder in which an abnormal number of chromosomes in a cell leads to genetic disorders, including Down syndrome, Edwards syndrome, and Patau syndrome. Preimplantation of genetic testing for aneuploidy (PGT-A) identifies embryos with chromosomal abnormalities before implantation, increasing the chances of a successful pregnancy outcome. Gender identification through preimplantation genetic testing allows couples to choose the gender of their child for family balancing or to avoid sex-linked disorders. Human leukocyte antigen (HLA) typing matches tissue types between donor and recipient for stem cell or organ transplantation procedures. Preimplantation HLA typing identifies embryos with compatible tissue types, potentially facilitating successful transplants in siblings with blood disorders or immune system deficiencies. Structural chromosomal abnormalities involve alterations in chromosome structure, including deletions, duplications, and rearrangements. In addition, X-linked diseases are caused by mutations in genes on the X chromosome, affecting males more severely than females.

  • End User: Increasing adoption of PGT in healthcare research organizations for accurate diagnosis and effective treatments

    Preimplantation genetics testing is widely used in various healthcare facilities, providing successful outcomes in clinical research. Contract research and manufacturing organizations (CRMOs) are primary organizations that play a crucial role in developing, manufacturing, and commercializing preimplantation genetic testing products. These organizations prefer outsourcing their services to ensure quality control, compliance with regulatory standards, and cost efficiency while focusing on their core competencies. Similarly, cryobanks are institutions that store biological samples such as sperm, eggs, and embryos at extremely low temperatures for future use. Preimplantation genetic testing is crucial for cryobanks to ensure the genetic viability of stored samples before implantation procedures like IVF or ICSI. Hospitals, diagnostic labs, and service providers contribute to patient care through accurate diagnosis and effective treatments using preimplantation genetic testing technologies. Research laboratories and academic institutes play a vital role in driving innovation and advancements in preimplantation genetic testing through cutting-edge research, technological developments, and interdisciplinary collaborations. These institutions focus on developing novel techniques like next-generation sequencing (NGS) to enhance the accuracy of preimplantation genetic testing methods.

Market Disruption Analysis

The market disruption analysis delves into the core elements associated with market-influencing changes, including breakthrough technological advancements that introduce novel features, integration capabilities, regulatory shifts that could drive or restrain market growth, and the emergence of innovative market players challenging traditional paradigms. This analysis facilitates a competitive advantage by preparing players in the Preimplantation Genetic Testing Market to pre-emptively adapt to these market-influencing changes, enhances risk management by early identification of threats, informs calculated investment decisions, and drives innovation toward areas with the highest demand in the Preimplantation Genetic Testing Market.

Porter’s Five Forces Analysis

The porter's five forces analysis offers a simple and powerful tool for understanding, identifying, and analyzing the position, situation, and power of the businesses in the Preimplantation Genetic Testing Market. This model is helpful for companies to understand the strength of their current competitive position and the position they are considering repositioning into. With a clear understanding of where power lies, businesses can take advantage of a situation of strength, improve weaknesses, and avoid taking wrong steps. The tool identifies whether new products, services, or companies have the potential to be profitable. In addition, it can be very informative when used to understand the balance of power in exceptional use cases.

Value Chain & Critical Path Analysis

The value chain of the Preimplantation Genetic Testing Market encompasses all intermediate value addition activities, including raw materials used, product inception, and final delivery, aiding in identifying competitive advantages and improvement areas. Critical path analysis of the <> market identifies task sequences crucial for timely project completion, aiding resource allocation and bottleneck identification. Value chain and critical path analysis methods optimize efficiency, improve quality, enhance competitiveness, and increase profitability. Value chain analysis targets production inefficiencies, and critical path analysis ensures project timeliness. These analyses facilitate businesses in making informed decisions, responding to market demands swiftly, and achieving sustainable growth by optimizing operations and maximizing resource utilization.

Pricing Analysis

The pricing analysis comprehensively evaluates how a product or service is priced within the Preimplantation Genetic Testing Market. This evaluation encompasses various factors that impact the price of a product, including production costs, competition, demand, customer value perception, and changing margins. An essential aspect of this analysis is understanding price elasticity, which measures how sensitive the market for a product is to its price change. It provides insight into competitive pricing strategies, enabling businesses to position their products advantageously in the Preimplantation Genetic Testing Market.

Technology Analysis

The technology analysis involves evaluating the current and emerging technologies relevant to a specific industry or market. This analysis includes breakthrough trends across the value chain that directly define the future course of long-term profitability and overall advancement in the Preimplantation Genetic Testing Market.

Patent Analysis

The patent analysis involves evaluating patent filing trends, assessing patent ownership, analyzing the legal status and compliance, and collecting competitive intelligence from patents within the Preimplantation Genetic Testing Market and its parent industry. Analyzing the ownership of patents, assessing their legal status, and interpreting the patents to gather insights into competitors' technology strategies assist businesses in strategizing and optimizing product positioning and investment decisions.

Trade Analysis

The trade analysis of the Preimplantation Genetic Testing Market explores the complex interplay of import and export activities, emphasizing the critical role played by key trading nations. This analysis identifies geographical discrepancies in trade flows, offering a deep insight into regional disparities to identify geographic areas suitable for market expansion. A detailed analysis of the regulatory landscape focuses on tariffs, taxes, and customs procedures that significantly determine international trade flows. This analysis is crucial for understanding the overarching legal framework that businesses must navigate.

Regulatory Framework Analysis

The regulatory framework analysis for the Preimplantation Genetic Testing Market is essential for ensuring legal compliance, managing risks, shaping business strategies, fostering innovation, protecting consumers, accessing markets, maintaining reputation, and managing stakeholder relations. Regulatory frameworks shape business strategies and expansion initiatives, guiding informed decision-making processes. Furthermore, this analysis uncovers avenues for innovation within existing regulations or by advocating for regulatory changes to foster innovation.

FPNV Positioning Matrix

The FPNV positioning matrix is essential in evaluating the market positioning of the vendors in the Preimplantation Genetic Testing Market. This matrix offers a comprehensive assessment of vendors, examining critical metrics related to business strategy and product satisfaction. This in-depth assessment empowers users to make well-informed decisions aligned with their requirements. Based on the evaluation, the vendors are then categorized into four distinct quadrants representing varying levels of success, namely Forefront (F), Pathfinder (P), Niche (N), or Vital (V).

Market Share Analysis

The market share analysis is a comprehensive tool that provides an insightful and in-depth assessment of the current state of vendors in the Preimplantation Genetic Testing Market. By meticulously comparing and analyzing vendor contributions, companies are offered a greater understanding of their performance and the challenges they face when competing for market share. These contributions include overall revenue, customer base, and other vital metrics. Additionally, this analysis provides valuable insights into the competitive nature of the sector, including factors such as accumulation, fragmentation dominance, and amalgamation traits observed over the base year period studied. With these illustrative details, vendors can make more informed decisions and devise effective strategies to gain a competitive edge in the market.

Recent Developments
  • Thermo Fisher Unveils Ion ReproSeq PGT-A Kit and Ion AmpliSeq Polyploidy Kit

    Thermo Fisher Scientific introduced two new reproductive health tests, namely the Ion ReproSeq PGT-A Kit and the Ion AmpliSeq Polyploidy Kit. The newly introduced tests aim to revolutionize fertility research and contribute to the improvement of future generations' health. [Published On: 2023-07-18]

  • Kindbody Brings Genetic Testing In-House with the Launch of Kindlabs

    Kindbody, a fertility network and benefits provider, announced the launch of Kindlabs, its in-house genetic testing division. Kindlabs offers a comprehensive range of genetic tests that adhere to stringent quality standards, aiming to optimize the chances of a successful pregnancy. [Published On: 2023-06-28]

  • Medicover Genetics and Fimlab Laboratories Announce Partnership to Provide Genetic Testing Services in Finland

    Medicover Genetics and Medicover Diagnostics Finland partnered with Fimlab Laboratories to offer genetic testing services to patients in Finland. This partnership is a significant milestone for Medicover Genetics as they continue to seek strategic collaborations and expand their services to new regions. [Published On: 2023-06-26]

Strategy Analysis & Recommendation

The strategic analysis is essential for organizations seeking a solid foothold in the global marketplace. Companies are better positioned to make informed decisions that align with their long-term aspirations by thoroughly evaluating their current standing in the Preimplantation Genetic Testing Market. This critical assessment involves a thorough analysis of the organization’s resources, capabilities, and overall performance to identify its core strengths and areas for improvement.

Key Company Profiles

The report delves into recent significant developments in the Preimplantation Genetic Testing Market, highlighting leading vendors and their innovative profiles. These include Abbott Laboratories, Agilent Technologies, Inc., Bio-Rad Laboratories, Inc., Bio-Techne Corporation, Bioarray S.L., EUROPE IVF International s.r.o., F. Hoffmann-La Roche AG, Genea Limited, GENETiKS, Illumina, Inc., Invicta Genetics, Invitae Corporation, Juno Genetics, US Inc., Laboratory Corporation of America Holdings, MedGenome Labs Ltd., Merck KGaA, Natera, Inc., NextGen Genetics Holdings, LLC, Ovation Fertility, PacGenomics, PerkinElmer, Inc., Progyny, Inc., Qiagen N.V., Quest Diagnostics Incorporated, Reproductive Genetic Innovations, LLC, SEQUENCE46, LLC, Sysmex Corporation, Takara Bio Inc., The Cooper Companies Inc., Thermo Fisher Scientific Inc., Vitrolife Sweden AB, and Yikon Genomics (Shanghai) Co., Ltd..

Preimplantation Genetic Testing Market - Global Forecast 2024-2030
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Market Segmentation & Coverage

This research report categorizes the Preimplantation Genetic Testing Market to forecast the revenues and analyze trends in each of the following sub-markets:

  • Technology
    • Comparative Genomic Hybridization
    • Fluorescence in-Situ Hybridization
    • Next-Generation Sequencing
    • Polymerase Chain Reaction
    • Single-Nucleotide Polymorphism
  • Offering
    • Instruments
    • Reagents & Consumables
    • Software & Services
  • Procedure Type
    • Preimplantation Genetic Diagnosis
    • Preimplantation Genetic Screening
  • Application
    • Aneuploidy
    • Gender Identification
    • HLA Typing
    • Single Gene Disorders
    • Structural Chromosomal Abnormalities
      • Deletions
      • Duplications
      • Inversions
      • Translocations
    • X-Linked Disorders
  • End User
    • Contract Research & Manufacturing Organizations
    • Cryobanks
    • Hospitals, Diagnostic Labs, & Service Providers
    • Research Laboratories & Academic Institutes

  • Region
    • Americas
      • Argentina
      • Brazil
      • Canada
      • Mexico
      • United States
        • California
        • Florida
        • Illinois
        • New York
        • Ohio
        • Pennsylvania
        • Texas
    • Asia-Pacific
      • Australia
      • China
      • India
      • Indonesia
      • Japan
      • Malaysia
      • Philippines
      • Singapore
      • South Korea
      • Taiwan
      • Thailand
      • Vietnam
    • Europe, Middle East & Africa
      • Denmark
      • Egypt
      • Finland
      • France
      • Germany
      • Israel
      • Italy
      • Netherlands
      • Nigeria
      • Norway
      • Poland
      • Qatar
      • Russia
      • Saudi Arabia
      • South Africa
      • Spain
      • Sweden
      • Switzerland
      • Turkey
      • United Arab Emirates
      • United Kingdom

This research report offers invaluable insights into various crucial aspects of the Preimplantation Genetic Testing Market:

  1. Market Penetration: This section thoroughly overviews the current market landscape, incorporating detailed data from key industry players.
  2. Market Development: The report examines potential growth prospects in emerging markets and assesses expansion opportunities in mature segments.
  3. Market Diversification: This includes detailed information on recent product launches, untapped geographic regions, recent industry developments, and strategic investments.
  4. Competitive Assessment & Intelligence: An in-depth analysis of the competitive landscape is conducted, covering market share, strategic approaches, product range, certifications, regulatory approvals, patent analysis, technology developments, and advancements in the manufacturing capabilities of leading market players.
  5. Product Development & Innovation: This section offers insights into upcoming technologies, research and development efforts, and notable advancements in product innovation.

Additionally, the report addresses key questions to assist stakeholders in making informed decisions:

  1. What is the current market size and projected growth?
  2. Which products, segments, applications, and regions offer promising investment opportunities?
  3. What are the prevailing technology trends and regulatory frameworks?
  4. What is the market share and positioning of the leading vendors?
  5. What revenue sources and strategic opportunities do vendors in the market consider when deciding to enter or exit?

Table of Contents
  1. Preface
  2. Research Methodology
  3. Executive Summary
  4. Market Overview
  5. Market Insights
  6. Preimplantation Genetic Testing Market, by Technology
  7. Preimplantation Genetic Testing Market, by Offering
  8. Preimplantation Genetic Testing Market, by Procedure Type
  9. Preimplantation Genetic Testing Market, by Application
  10. Preimplantation Genetic Testing Market, by End User
  11. Americas Preimplantation Genetic Testing Market
  12. Asia-Pacific Preimplantation Genetic Testing Market
  13. Europe, Middle East & Africa Preimplantation Genetic Testing Market
  14. Competitive Landscape
  15. Competitive Portfolio
  16. List of Figures [Total: 26]
  17. List of Tables [Total: 568]
  18. List of Companies Mentioned [Total: 32]
The Advancement of Preimplantation Genetic Testing
October 13, 2023
BLOG
The Advancement of Preimplantation Genetic Testing
The journey towards achieving a healthy pregnancy is a challenging one. It can be even more complicated for individuals or couples with a family history or genetic predisposition to certain illnesses. However, with advancements in preimplantation genetic testing, couples can now conceive more confidently. Preimplantation genetic testing involves screening fertilized eggs for abnormalities before implantation, ultimately reducing the likelihood of transferring genetic conditions to offspring. This blog post explores how preimplantation genetic analysis continually evolves and increases the scope of preimplantation genetic testing.

Advancements in Next-Generation Sequencing:

Next-generation sequencing is one of the most significant advancements in preimplantation genetic testing. This technology has allowed for the screening of embryos for genetic disorders that were previously undetectable. Next-generation sequencing uses a highly sensitive technique to read strands of DNA. It can accurately identify abnormalities and detect specific genes that predispose individuals to inherited disorders. As a result, this technology has significantly increased the accuracy of preimplantation genetic testing, giving couples greater confidence in their pregnancy journey.

New Techniques for Identifying Copy-Number Variant:

Copy number variants (CNVs) are structural alterations in the genome responsible for many genetic disorders. The ability to identify CNVs within preimplantation embryos has significantly improved with recent advancements. This is due to the introduction of Comparative Genomic Hybridization (CGH) and Single-Nucleotide Polymorphism (SNP) arrays for chromosomal analysis. These new techniques increase the accuracy of identifying CNVs in embryos, reducing the likelihood of transferring genetic disorders to the offspring.

The Benefits of Time-Lapse Imaging:

Time-lapse imaging has been instrumental in developing preimplantation genetic testing, providing embryologists with real-time visuals of a fertilized egg's development. This technology has revolutionized how embryos are monitored and has led to increased embryo implantation rates. Time-lapse imaging allows for early detection of embryonic anomalies, identifying which embryos are more likely to develop into healthy pregnancies.

Increasing the Number of Embryonic Biopsies:

Traditionally, preimplantation genetic testing involved only a single biopsy of an embryo. However, recent advancements in preimplantation genetic testing have led to an increase in the number of biopsies taken from each embryo. By increasing the number of biopsies taken, embryologists can screen for multiple genetic disorders and increase the chances of detecting abnormalities. Higher accuracy in identifying genetic disorders leads to a higher implantation rate and significantly increases the chances of a healthy pregnancy.

Advances in Artificial Intelligence:

Artificial intelligence (AI) advancements have played a significant role in increasing the accuracy of preimplantation genetic testing. AI algorithms can analyze large amounts of data in real time, improving the efficiency of identifying mistakes, reducing the amount of human error involved, and increasing the accuracy of screening for genetic disorders. By incorporating AI into preimplantation genetic testing, we can further increase the safety and efficacy of the process.

The advancements in preimplantation genetic testing represent a significant leap forward in reproductive medicine. These advancements improve the accuracy of detecting genetic disorders, increasing the chances of a healthy pregnancy. With these new techniques, couples can move forward more confidently in their pregnancy journey. As new technologies are introduced, we can expect that preimplantation genetic testing will continue to evolve, providing individuals with the highest quality of reproductive medicine available.

Frequently Asked Questions
  1. How big is the Preimplantation Genetic Testing Market?
    Ans. The Global Preimplantation Genetic Testing Market size was estimated at USD 728.40 million in 2023 and expected to reach USD 829.06 million in 2024.
  2. What is the Preimplantation Genetic Testing Market growth?
    Ans. The Global Preimplantation Genetic Testing Market to grow USD 1,886.28 million by 2030, at a CAGR of 14.56%
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